sys·tem·ic (sĭ-stĕmĭk, -stēmĭk)
1. Of or relating to systems or a system.
a. Relating to or affecting the entire body or an entire organism: systemic symptoms; a systemic poison.
b. Relating to or affecting a particular body system, especially the nervous system: a systemic lesion.
c. Physiology Of or relating to systemic circulation.
The American Heritage® Dictionary of the English Language, Fifth Edition copyright ©2020 by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Indo-European & Semitic Roots Appendices
Thousands of entries in the dictionary include etymologies that trace their origins back to reconstructed proto-languages. You can obtain more information about these forms in our online appendices:
The Indo-European appendix covers nearly half of the Indo-European roots that have left their mark on English words. A more complete treatment of Indo-European roots and the English words derived from them is available in our Dictionary of Indo-European Roots.