sys·tem·ic (sĭ-stĕmĭk, -stēmĭk)
1. Of or relating to systems or a system.
a. Relating to or affecting the entire body or an entire organism: systemic symptoms; a systemic poison.
b. Relating to or affecting a particular body system, especially the nervous system: a systemic lesion.
c. Physiology Of or relating to systemic circulation.
The American Heritage® Dictionary of the English Language, Fifth Edition copyright ©2018 by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
The American Heritage Dictionary Blog
Check out our blog, updated regularly, for new words and revised definitions, interesting images from the 5th edition, discussions of usage, and more.