n. pl. flies 1. a. Any of numerous two-winged insects of the order Diptera, especially any of the family Muscidae, which includes the housefly.
b. Any of various other flying insects, such as a caddisfly.
2. A fishing lure simulating something a fish eats, such as a mayfly or a minnow, made by attaching materials such as feathers, tinsel, and colored thread to a fishhook.