Tay-Sachs disease (tāsăks′)
A hereditary disease that affects young children almost exclusively of eastern European Jewish descent, in which an enzyme deficiency leads to the accumulation of gangliosides in the brain and nerve tissue, resulting in intellectual disability, convulsions, blindness, and, ultimately, death.
[After Warren Tay (1843-1927), British physician, and Bernard Sachs (1858-1944), American neurologist.]
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